Benzodiazepines, Urine, Quantitative

Methodology: Quantitative Liquid Chromatography-Tandem Mass Spectrometry

Drugs covered: alprazolam, alpha-hydroxyalprazolam, chlordiazepoxide, clonazepam, 7-aminoclonazepam, diazepam, lorazepam, midazolam, alpha-hydroxymidazolam, nordiazepam, oxazepam and temazepam.. 

Positive cutoff: 20 ng/mL unless specified below:
Alprazolam: 5 ng/mL
Alpha-hydroxyalprazolam: 5 ng/mL
Clonazepam: 5 ng/mL
7-aminoclonazepam: 5 ng/mL

For medical purposes only; not valid for forensic use.

Identification of specific drug(s) taken by specimen donor is problematic due to common metabolites, some of which are prescription drugs themselves. The absence of expected drug(s) and/or drug metabolite(s) may indicate noncompliance, inappropriate timing of specimen collection relative to drug administration, poor drug absorption, diluted/adulterated urine, or limitations of testing. The concentration value must be greater than or equal to the cutoff to be reported as positive. Interpretive questions should be directed to the laboratory.